Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic …
M Shimizu, A Hara, M Okuno, H Matsuno, K Okada… - Hepatology, 2001 - Elsevier
Urokinase-type plasminogen activator (uPA) is implicated in the regulation of hepatic
regeneration by activating hepatocyte growth factor (HGF). Here, we investigated its role in
the hepatic regeneration after Fas-mediated massive hepatocyte death employing mice
deficient in either uPA or its inhibitor, plasminogen activator inhibitor-1 (PAI-1). We
measured kinetics of hepatic levels of proliferating cell nuclear antigen (PCNA)-labeling
index, plasmin activity, mature HGF, and its phosphorylated receptor, c-Met. In the …
regeneration by activating hepatocyte growth factor (HGF). Here, we investigated its role in
the hepatic regeneration after Fas-mediated massive hepatocyte death employing mice
deficient in either uPA or its inhibitor, plasminogen activator inhibitor-1 (PAI-1). We
measured kinetics of hepatic levels of proliferating cell nuclear antigen (PCNA)-labeling
index, plasmin activity, mature HGF, and its phosphorylated receptor, c-Met. In the …
