[HTML][HTML] Animal models of tremor: relevance to human tremor disorders
Background Tremor is the most common movement disorder; however, the pathophysiology
of tremor remains elusive. While several neuropathological alterations in tremor disorders
have been observed in post-mortem studies of human brains, a full understanding of the
relationship between brain circuitry alterations and tremor requires testing in animal models.
Additionally, tremor animal models are critical for our understanding of tremor
pathophysiology, and/or to serve as a platform for therapy development. Methods
of tremor remains elusive. While several neuropathological alterations in tremor disorders
have been observed in post-mortem studies of human brains, a full understanding of the
relationship between brain circuitry alterations and tremor requires testing in animal models.
Additionally, tremor animal models are critical for our understanding of tremor
pathophysiology, and/or to serve as a platform for therapy development. Methods
Abstract
Background
Tremor is the most common movement disorder; however, the pathophysiology of tremor remains elusive. While several neuropathological alterations in tremor disorders have been observed in post-mortem studies of human brains, a full understanding of the relationship between brain circuitry alterations and tremor requires testing in animal models. Additionally, tremor animal models are critical for our understanding of tremor pathophysiology, and/or to serve as a platform for therapy development.
Methods
ncbi.nlm.nih.gov
