[HTML][HTML] Synaptotagmins: why so many?
TC Südhof - Journal of Biological Chemistry, 2002 - ASBMB
Synaptotagmins constitute a family of membrane-trafficking proteins that are characterized
by an N-terminal TMR, 1 a variable linker, and two C-terminal C2-domains (1).
Synaptotagmin 1 (Syt 1) was identified as p65 in a monoclonal antibody screen for synaptic
proteins (2) and proposed as a potential Ca2 sensor for regulated exocytosis when its
cloning revealed the presence of two C2-domains (3). Twelve additional synaptotagmins
were subsequently discovered (Fig. 1 and Table I; Refs. 4–14). Extensive work showed that …
by an N-terminal TMR, 1 a variable linker, and two C-terminal C2-domains (1).
Synaptotagmin 1 (Syt 1) was identified as p65 in a monoclonal antibody screen for synaptic
proteins (2) and proposed as a potential Ca2 sensor for regulated exocytosis when its
cloning revealed the presence of two C2-domains (3). Twelve additional synaptotagmins
were subsequently discovered (Fig. 1 and Table I; Refs. 4–14). Extensive work showed that …
