Background & Aims The liver is the main hematopoietic site in embryos, becoming a crucial
organ in both immunity and metabolism in adults. However, how the liver adapts both the
immune system and enzymatic profile to challenges in the postnatal period remains elusive.
We aimed to identify the mechanisms underlying this adaptation. Methods We analyzed liver
samples from mice on day 0 after birth until adulthood. Human biopsies from newborns and
adults were also examined. Liver immune cells were phenotyped using mass cytometry …