α-Synuclein and Lewy pathology in Parkinson's disease
These recent findings open up new avenues of investigation into the molecular
pathogenesis of Parkinson's disease. Future work will need to identify the most toxic
conformations of α-synuclein and define their relationship to Lewy pathology. This work will
be necessary to be able to develop novel therapeutic strategies that target specific
pathogenic forms of α-synuclein for disease modification in Parkinson's disease.
pathogenesis of Parkinson's disease. Future work will need to identify the most toxic
conformations of α-synuclein and define their relationship to Lewy pathology. This work will
be necessary to be able to develop novel therapeutic strategies that target specific
pathogenic forms of α-synuclein for disease modification in Parkinson's disease.
Summary
These recent findings open up new avenues of investigation into the molecular pathogenesis of Parkinson's disease. Future work will need to identify the most toxic conformations of α-synuclein and define their relationship to Lewy pathology. This work will be necessary to be able to develop novel therapeutic strategies that target specific pathogenic forms of α-synuclein for disease modification in Parkinson's disease.
Lippincott Williams & Wilkins