Challenges in interpreting multivariable Mendelian randomization: might “good cholesterol” be good after all?

MV Holmes, GD Smith - American Journal of Kidney Diseases, 2018 - ajkd.org
Understanding the causal basis of disease is important so that we approach disease
prevention and treatment using a valid etiologic framework. Blood lipids play an important
role in the shuttling of nutrients (in the form of triglycerides and fatty acids) and cholesterol
from the diet to the peripheral tissues. Certain types of blood lipids (eg, low-density
lipoprotein cholesterol [LDL-C] and probably triglycerides [TG]) are atherogenic and lead to
higher risks for coronary heart disease (CHD). 1-6 The role of highdensity lipoprotein …