Role for CD4+ CD25+ T cells in inhibition of graft rejection by extracorporeal photopheresis
JF George, CW Gooden, WH Guo, JK Kirklin - The Journal of heart and lung …, 2008 - Elsevier
BACKGROUND: Extracorporeal photopheresis (ECP) is used to treat recurrent severe
rejection in clinical heart and lung recipients. The mechanisms of the salutary effects of ECP
are poorly understood, but appear to involve regulation of T-cell–mediated alloreactive
responses, possibly by induction of regulatory T cells. We created a mouse model of ECP to
determine the effects of ECP on T-cell responses in vivo and the contribution of CD4+
CD25+ T cells. METHODS: In this study, 1× 107 splenocytes were treated with 8 …
rejection in clinical heart and lung recipients. The mechanisms of the salutary effects of ECP
are poorly understood, but appear to involve regulation of T-cell–mediated alloreactive
responses, possibly by induction of regulatory T cells. We created a mouse model of ECP to
determine the effects of ECP on T-cell responses in vivo and the contribution of CD4+
CD25+ T cells. METHODS: In this study, 1× 107 splenocytes were treated with 8 …
