Florbetapir-PET Imaging and Postmortem β-Amyloid Pathology—Reply
CM Clark, MA Mintun, MJ Pontecorvo - Jama, 2011 - jamanetwork.com
To the Editor: In their study on the use of florbetapir for positron emission tomographic (PET)
imaging of brain-amyloid, 1 Dr Clark and colleagues submitted to JAMA median values for
PET scan reader scores but withheld critical individual reader score data that Avid
Radiopharmaceuticals submitted to the Food and Drug Administration (FDA) on September
17, 2010. FDA analyses of these data show substantial interreader variability among
independent, extensively trained readers of the florbetapir-PET scans for individuals in the …
imaging of brain-amyloid, 1 Dr Clark and colleagues submitted to JAMA median values for
PET scan reader scores but withheld critical individual reader score data that Avid
Radiopharmaceuticals submitted to the Food and Drug Administration (FDA) on September
17, 2010. FDA analyses of these data show substantial interreader variability among
independent, extensively trained readers of the florbetapir-PET scans for individuals in the …