Importance Delirium is associated with accelerated cognitive decline. The pathologic
substrates of this association are not yet known, that is, whether they are the same as those
associated with dementia, are independent, or are interrelated. Objective To examine
whether the accelerated cognitive decline observed after delirium is independent of the
pathologic processes of classic dementia. Design, Setting, and Participants Harmonized
data from 987 individual brain donors from 3 observational cohort studies with population …