[HTML][HTML] Histone deacetylase 3 coordinates deacetylase-independent epigenetic silencing of transforming growth factor-β1 (TGF-β1) to orchestrate second heart field …
SL Lewandowski, HP Janardhan, CM Trivedi - Journal of Biological …, 2015 - ASBMB
About two-thirds of human congenital heart disease involves second heart field-derived
structures. Histone-modifying enzymes, histone deacetylases (HDACs), regulate the
epigenome; however, their functions within the second heart field remain elusive. Here we
demonstrate that histone deacetylase 3 (HDAC3) orchestrates epigenetic silencing of Tgf-
β1, a causative factor in congenital heart disease pathogenesis, in a deacetylase-
independent manner to regulate development of second heart field-derived structures. In …
structures. Histone-modifying enzymes, histone deacetylases (HDACs), regulate the
epigenome; however, their functions within the second heart field remain elusive. Here we
demonstrate that histone deacetylase 3 (HDAC3) orchestrates epigenetic silencing of Tgf-
β1, a causative factor in congenital heart disease pathogenesis, in a deacetylase-
independent manner to regulate development of second heart field-derived structures. In …