[HTML][HTML] Sensitive protein alignments at tree-of-life scale using DIAMOND
B Buchfink, K Reuter, HG Drost - Nature methods, 2021 - nature.com
B Buchfink, K Reuter, HG Drost
Nature methods, 2021•nature.comWe are at the beginning of a genomic revolution in which all known species are planned to
be sequenced. Accessing such data for comparative analyses is crucial in this new age of
data-driven biology. Here, we introduce an improved version of DIAMOND that greatly
exceeds previous search performances and harnesses supercomputing to perform tree-of-
life scale protein alignments in hours, while matching the sensitivity of the gold standard
BLASTP.
be sequenced. Accessing such data for comparative analyses is crucial in this new age of
data-driven biology. Here, we introduce an improved version of DIAMOND that greatly
exceeds previous search performances and harnesses supercomputing to perform tree-of-
life scale protein alignments in hours, while matching the sensitivity of the gold standard
BLASTP.
Abstract
We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.
nature.com