[HTML][HTML] The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-κB from Toll-like receptor 4
W Dong, Y Liu, J Peng, L Chen, T Zou, H Xiao… - Journal of biological …, 2006 - ASBMB
Our previous studies have revealed that the signaling protein BCL10 plays a major role in
adaptive immunity by mediating NF-κB activation in the LPS/TLR4 pathway. In this study, we
show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4
signaling complex and mediates signaling to NF-κB through the BCL10-MALT1-TRAF6-
TAK1 cascade. Following dissociation from IRAK-1, BCL10 is translocated into the cytosol
along with TRAF6 and TAK1, in a process bridged by a direct BCL10-Pellino2 interaction …
adaptive immunity by mediating NF-κB activation in the LPS/TLR4 pathway. In this study, we
show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4
signaling complex and mediates signaling to NF-κB through the BCL10-MALT1-TRAF6-
TAK1 cascade. Following dissociation from IRAK-1, BCL10 is translocated into the cytosol
along with TRAF6 and TAK1, in a process bridged by a direct BCL10-Pellino2 interaction …
