Classifying collective cancer cell invasion
Most invasive solid tumours display predominantly collective invasion, in which groups of
cells invade the peritumoral stroma while maintaining cell–cell contacts. As the concepts
and experimental models for functional analysis of collective cancer cell invasion are rapidly
developing, we propose a framework for addressing potential mechanisms, experimental
strategies and technical challenges to study this process.
cells invade the peritumoral stroma while maintaining cell–cell contacts. As the concepts
and experimental models for functional analysis of collective cancer cell invasion are rapidly
developing, we propose a framework for addressing potential mechanisms, experimental
strategies and technical challenges to study this process.
Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell–cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addressing potential mechanisms, experimental strategies and technical challenges to study this process.
nature.com