[HTML][HTML] Web-based survival analysis tool tailored for medical research (KMplot): development and implementation
A Lánczky, B Győrffy - Journal of medical Internet research, 2021 - jmir.org
A Lánczky, B Győrffy
Journal of medical Internet research, 2021•jmir.orgBackground Survival analysis is a cornerstone of medical research, enabling the
assessment of clinical outcomes for disease progression and treatment efficiency. Despite
its central importance, no commonly used spreadsheet software can handle survival
analysis and there is no web server available for its computation. Objective Here, we
introduce a web-based tool capable of performing univariate and multivariate Cox
proportional hazards survival analysis using data generated by genomic, transcriptomic …
assessment of clinical outcomes for disease progression and treatment efficiency. Despite
its central importance, no commonly used spreadsheet software can handle survival
analysis and there is no web server available for its computation. Objective Here, we
introduce a web-based tool capable of performing univariate and multivariate Cox
proportional hazards survival analysis using data generated by genomic, transcriptomic …
Background
Survival analysis is a cornerstone of medical research, enabling the assessment of clinical outcomes for disease progression and treatment efficiency. Despite its central importance, no commonly used spreadsheet software can handle survival analysis and there is no web server available for its computation.
Objective
Here, we introduce a web-based tool capable of performing univariate and multivariate Cox proportional hazards survival analysis using data generated by genomic, transcriptomic, proteomic, or metabolomic studies.
Methods
We implemented different methods to establish cut-off values for the trichotomization or dichotomization of continuous data. The false discovery rate is computed to correct for multiple hypothesis testing. A multivariate analysis option enables comparing omics data with clinical variables.
Results
We established a registration-free web-based survival analysis tool capable of performing univariate and multivariate survival analysis using any custom-generated data.
Conclusions
This tool fills a gap and will be an invaluable contribution to basic medical and clinical research.
jmir.org