[HTML][HTML] Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
GL Razidlo, KM Burton, MA McNiven - Journal of Biological Chemistry, 2018 - ASBMB
Inflammation is a major driver of tumor progression and metastasis, although the
mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown.
Interleukin-6 (IL-6) is a potent proinflammatory cytokine that is elevated in individuals with
pancreatic cancer (PDAC), is required for PDAC progression in mice, and increases tumor
cell invasion in vitro. Here, we provide insights into the mechanisms by which IL-6 activates
tumor cell invasion. We found that IL-6 stimulation rapidly and robustly activates the small …
mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown.
Interleukin-6 (IL-6) is a potent proinflammatory cytokine that is elevated in individuals with
pancreatic cancer (PDAC), is required for PDAC progression in mice, and increases tumor
cell invasion in vitro. Here, we provide insights into the mechanisms by which IL-6 activates
tumor cell invasion. We found that IL-6 stimulation rapidly and robustly activates the small …