Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens
EA Severson, GM Riedlinger… - Blood, The Journal …, 2018 - ashpublications.org
Blood, The Journal of the American Society of Hematology, 2018•ashpublications.org
Clonal hematopoiesis of indeterminate potential (CHIP) describes an expansion of
hematopoietic stem cells that harbor somatic mutations1-5 without an underlying
hematologic malignancy or definitive morphologic evidence of dysplasia. 6 CHIP can evolve
to overt neoplasia, with a progression rate of 0.5% to 1.0% per year. 2, 3 CHIP was first
identified through genomic profiling of peripheral blood from healthy individuals. 1-5 Its
incidence increases with age and has been detected in peripheral blood of patients with …
hematopoietic stem cells that harbor somatic mutations1-5 without an underlying
hematologic malignancy or definitive morphologic evidence of dysplasia. 6 CHIP can evolve
to overt neoplasia, with a progression rate of 0.5% to 1.0% per year. 2, 3 CHIP was first
identified through genomic profiling of peripheral blood from healthy individuals. 1-5 Its
incidence increases with age and has been detected in peripheral blood of patients with …
Clonal hematopoiesis of indeterminate potential (CHIP) describes an expansion of hematopoietic stem cells that harbor somatic mutations1-5 without an underlying hematologic malignancy or definitive morphologic evidence of dysplasia. 6 CHIP can evolve to overt neoplasia, with a progression rate of 0.5% to
1.0% per year. 2, 3 CHIP was first identified through genomic profiling of peripheral blood from healthy individuals. 1-5 Its incidence increases with age and has been detected in peripheral blood of patients with solid tumors. 7, 8 In elderly cancer patients, the presence of CHIP prior to chemotherapeutic exposure is
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