Assignment [sup 1] of IκB kinase β (IKBKB) to human chromosome band 8p12→ p11 by in situ hybridization.
M Shindo, H Nakano, S Sakon… - Cytogenetics & Cell …, 1998 - search.ebscohost.com
M Shindo, H Nakano, S Sakon, H Yagita, M Mihara, K Okumuraa
Cytogenetics & Cell Genetics, 1998•search.ebscohost.comAbstract NF-& b. kappa; B is composed of hetero-or homodimers of Rel family proteins
and is involved in inflammatory response, growth control, and cell death. In unstimulated
cells, NF-& b. kappa; B is sequestered in the cytoplasm as a complex with inhibitory
proteins called I& b. kappa; Bs. Various stimuli activating NF-& b. kappa; B result in
phosphorylation of two serines at the N-terminus of I& b. kappa; Bα and I& b.
kappa; BΒ and subsequent degradation of them, resulting in translocation of NF-& b …
and is involved in inflammatory response, growth control, and cell death. In unstimulated
cells, NF-& b. kappa; B is sequestered in the cytoplasm as a complex with inhibitory
proteins called I& b. kappa; Bs. Various stimuli activating NF-& b. kappa; B result in
phosphorylation of two serines at the N-terminus of I& b. kappa; Bα and I& b.
kappa; BΒ and subsequent degradation of them, resulting in translocation of NF-& b …
Abstract NF-& b. kappa; B is composed of hetero-or homodimers of Rel family proteins and is involved in inflammatory response, growth control, and cell death. In unstimulated cells, NF-& b. kappa; B is sequestered in the cytoplasm as a complex with inhibitory proteins called I& b. kappa; Bs. Various stimuli activating NF-& b. kappa; B result in phosphorylation of two serines at the N-terminus of I& b. kappa; Bα and I& b. kappa; BΒ and subsequent degradation of them, resulting in translocation of NF-& b. kappa; B into the nucleus and activation of target genes. A previous study showed that the I& b. kappa; B kinase forms a large complex with a molecular mass of 700 kDa.
search.ebscohost.com