Selenium is a micronutrient that is essential for the production of normal spermatozoa. The
selenium-rich plasma protein selenoprotein P (Sepp1) is required for maintenance of testis
selenium and for fertility of the male mouse. Sepp1 trafficking in the seminiferous epithelium
was studied using conventional methods and mice with gene deletions.
Immunocytochemistry demonstrated that Sepp1 is present in vesicle-like structures in the
basal region of Sertoli cells, suggesting that the protein is taken up intact. Sepp1 affinity …