[HTML][HTML] Deletion of selenoprotein P alters distribution of selenium in the mouse
KE Hill, J Zhou, WJ McMahan, AK Motley… - Journal of Biological …, 2003 - ASBMB
Selenoprotein P (Se-P) contains most of the selenium in plasma. Its function is not known.
Mice with the Se-P gene deleted (Sepp−/−) were generated. Two phenotypes were
observed: 1) Sepp−/− mice lost weight and developed poor motor coordination when fed
diets with selenium below 0.1 mg/kg, and 2) maleSepp−/− mice had sharply reduced fertility.
Weanling male Sepp+/+, Sepp+/−, and Sepp−/− mice were fed diets for 8 weeks containing<
0.02–2 mg selenium/kg. Sepp+/+ and Sepp+/− mice had similar selenium concentrations in …
Mice with the Se-P gene deleted (Sepp−/−) were generated. Two phenotypes were
observed: 1) Sepp−/− mice lost weight and developed poor motor coordination when fed
diets with selenium below 0.1 mg/kg, and 2) maleSepp−/− mice had sharply reduced fertility.
Weanling male Sepp+/+, Sepp+/−, and Sepp−/− mice were fed diets for 8 weeks containing<
0.02–2 mg selenium/kg. Sepp+/+ and Sepp+/− mice had similar selenium concentrations in …