[HTML][HTML] Alternatively activated macrophages promote resolution of necrosis following acute liver injury
PS Lewis, L Campana, N Aleksieva, JA Cartwright… - Journal of …, 2020 - Elsevier
Background & Aim Following acetaminophen (APAP) overdose, acute liver injury (ALI) can
occur in patients that present too late for N-acetylcysteine treatment, potentially leading to
acute liver failure, systemic inflammation, and death. Macrophages influence the
progression and resolution of ALI due to their innate immunological function and paracrine
activity. Syngeneic primary bone marrow-derived macrophages (BMDMs) were tested as a
cell-based therapy in a mouse model of APAP-induced ALI (APAP-ALI). Methods Several …
occur in patients that present too late for N-acetylcysteine treatment, potentially leading to
acute liver failure, systemic inflammation, and death. Macrophages influence the
progression and resolution of ALI due to their innate immunological function and paracrine
activity. Syngeneic primary bone marrow-derived macrophages (BMDMs) were tested as a
cell-based therapy in a mouse model of APAP-induced ALI (APAP-ALI). Methods Several …