Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis
M Hatano, S Sasaki, S Ohata, Y Shiratsuchi… - Cellular …, 2008 - Elsevier
TNF-α, IFN-γ, IL-4, and MIP-2 are known to be involved in Con A-induced hepatitis. Although
Kupffer cells are reportedly involved in TNF-α production, it is largely unknown whether or
not Kupffer cells also play a role in the production of other cytokines, such as IFN-γ, IL-4, and
MIP-2. In this study we examined the liver injury and the levels of plasma cytokines,
including above four cytokines, KC, and IL-10 in Kupffer cell-depleted mice obtained through
administration of liposome-encapsulated dichloromethylene bisphosphonate. The liver …
Kupffer cells are reportedly involved in TNF-α production, it is largely unknown whether or
not Kupffer cells also play a role in the production of other cytokines, such as IFN-γ, IL-4, and
MIP-2. In this study we examined the liver injury and the levels of plasma cytokines,
including above four cytokines, KC, and IL-10 in Kupffer cell-depleted mice obtained through
administration of liposome-encapsulated dichloromethylene bisphosphonate. The liver …