[HTML][HTML] Blockade of retinol metabolism protects T cell-induced hepatitis by increasing migration of regulatory T cells
Retinols are metabolized into retinoic acids by alcohol dehydrogenase (ADH) and
retinaldehyde dehydrogenase (Raldh). However, their roles have yet to be clarified in
hepatitis despite enriched retinols in hepatic stellate cells (HSCs). Therefore, we
investigated the effects of retinols on Concanavalin A (Con A)-mediated hepatitis. Con A
was injected into wild type (WT), Raldh1 knock-out (Raldh1−/−), CCL2−/− and CCR2−/−
mice. For migration study of regulatory T cells (Tregs), we used in vivo and ex vivo adoptive …
retinaldehyde dehydrogenase (Raldh). However, their roles have yet to be clarified in
hepatitis despite enriched retinols in hepatic stellate cells (HSCs). Therefore, we
investigated the effects of retinols on Concanavalin A (Con A)-mediated hepatitis. Con A
was injected into wild type (WT), Raldh1 knock-out (Raldh1−/−), CCL2−/− and CCR2−/−
mice. For migration study of regulatory T cells (Tregs), we used in vivo and ex vivo adoptive …