The cysteine protease legumain (asparaginyl endopeptidase, AEP) plays important roles in
normal physiology but is also associated with several disorders, such as atherosclerosis,
osteoporosis, cancer and neurodegenerative diseases. The functional roles of legumain
have mainly been associated with the presence in lysosomes where legumain is active and
mediates processing of multiple proteins, such as the conversion of single to double chain
forms of cysteine cathepsins. However, in recent years, a number of studies point to …