[HTML][HTML] Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases
E Devroe, H Erdjument-Bromage, P Tempst… - Journal of Biological …, 2004 - ASBMB
Human NDR1 (nuclear Dbf2-related) is a widely expressed nuclear serine-threonine kinase
that has been implicated in cell proliferation and/or tumor progression. Here we present
molecular characterization of the human NDR2 serine-threonine kinase, which shares∼
87% sequence identity with NDR1. NDR2 is expressed in most human tissues with the
highest expression in the thymus. In contrast to NDR1, NDR2 is excluded from the nucleus
and exhibits a punctate cytoplasmic distribution. The differential localization of NDR1 and …
that has been implicated in cell proliferation and/or tumor progression. Here we present
molecular characterization of the human NDR2 serine-threonine kinase, which shares∼
87% sequence identity with NDR1. NDR2 is expressed in most human tissues with the
highest expression in the thymus. In contrast to NDR1, NDR2 is excluded from the nucleus
and exhibits a punctate cytoplasmic distribution. The differential localization of NDR1 and …