[HTML][HTML] The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 …
HM El-Shewy, MH Lee, LM Obeid, AA Jaffa… - Journal of Biological …, 2007 - ASBMB
Insulin-like growth factor types 1 and 2 (IGF-1; IGF-2) and insulin-like peptides are all
members of the insulin superfamily of peptide hormones but bind to several distinct classes
of membrane receptor. Like the insulin receptor, the IGF-1 receptor is a heterotetrameric
receptor tyrosine kinase, whereas the IGF-2/mannose 6-phosphate receptor is a single
transmembrane domain protein that is thought to function primarily as clearance receptors.
We recently reported that IGF-1 and IGF-2 stimulate the ERK1/2 cascade by triggering …
members of the insulin superfamily of peptide hormones but bind to several distinct classes
of membrane receptor. Like the insulin receptor, the IGF-1 receptor is a heterotetrameric
receptor tyrosine kinase, whereas the IGF-2/mannose 6-phosphate receptor is a single
transmembrane domain protein that is thought to function primarily as clearance receptors.
We recently reported that IGF-1 and IGF-2 stimulate the ERK1/2 cascade by triggering …