MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus
B Garchow, M Kiriakidou - Clinical Immunology, 2016 - Elsevier
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression primarily
at the post-transcriptional level. Emerging evidence supports a regulatory role for miRNAs in
the immune response and autoimmunity. In this work, we investigated the implication of miR-
21 in the experimentally inducible bm12→ B6 cGVHD model of systemic lupus
erythematosus (SLE). cGVHD host mice deficient in miR-21 show a 2-fold reduction in
splenomegaly, significantly reduced autoantibody titers and down-regulated components of …
at the post-transcriptional level. Emerging evidence supports a regulatory role for miRNAs in
the immune response and autoimmunity. In this work, we investigated the implication of miR-
21 in the experimentally inducible bm12→ B6 cGVHD model of systemic lupus
erythematosus (SLE). cGVHD host mice deficient in miR-21 show a 2-fold reduction in
splenomegaly, significantly reduced autoantibody titers and down-regulated components of …