[HTML][HTML] Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus
Mutations in the genes encoding nuclear factor (erythroid-derived 2)-like 2 (NRF2), Kelch-
like ECH-associated protein 1 (KEAP1), and cullin 3 (CUL3) are commonly observed in
human esophageal squamous cell carcinoma (ESCC) and result in activation of the NRF2
signaling pathway. Moreover, hyperactivity of the transcription factor Nrf2 has been found to
cause esophageal hyperproliferation and hyperkeratosis in mice. However, the underlying
mechanism is unclear. In this study, we aimed to understand the molecular mechanisms of …
like ECH-associated protein 1 (KEAP1), and cullin 3 (CUL3) are commonly observed in
human esophageal squamous cell carcinoma (ESCC) and result in activation of the NRF2
signaling pathway. Moreover, hyperactivity of the transcription factor Nrf2 has been found to
cause esophageal hyperproliferation and hyperkeratosis in mice. However, the underlying
mechanism is unclear. In this study, we aimed to understand the molecular mechanisms of …