[HTML][HTML] Enrichment of regulatory T cells in acutely rejected human liver allografts
R Taubert, S Pischke, J Schlue, H Wedemeyer… - American Journal of …, 2012 - Elsevier
Acute cellular rejection (ACR) occurs frequently after liver transplantation and can usually be
controlled. Triggering of allospecific immune responses and lack of immunoregulation are
currently suggested as a cause of ACR, but there are no investigations of intrahepatic
immune responses during ACR. Therefore we prospectively analyzed the intrahepatic T cell
infiltration pattern in correlation to the severity of ACR in a cohort of patients with graft
hepatitis (n= 151). While CD4+ cells dominated the portal infiltrates in mild–moderate ACR …
controlled. Triggering of allospecific immune responses and lack of immunoregulation are
currently suggested as a cause of ACR, but there are no investigations of intrahepatic
immune responses during ACR. Therefore we prospectively analyzed the intrahepatic T cell
infiltration pattern in correlation to the severity of ACR in a cohort of patients with graft
hepatitis (n= 151). While CD4+ cells dominated the portal infiltrates in mild–moderate ACR …