[HTML][HTML] TIGIT agonism alleviates costimulation blockade-resistant rejection in a regulatory T cell–dependent manner
CR Hartigan, KP Tong, D Liu, SJ Laurie… - American Journal of …, 2023 - Elsevier
Belatacept-based immunosuppression in kidney transplantation confers fewer off-target
toxicities than calcineurin inhibitors but comes at a cost of increased incidence and severity
of acute rejection, potentially due to its deleterious effect on both the number and function of
Foxp3+ regulatory T cells (Tregs). TIGIT is a CD28 family coinhibitory receptor expressed on
several subsets of immune cells including Tregs. We hypothesized that coinhibition through
TIGIT signaling could function to ameliorate costimulation blockade-resistant rejection. The …
toxicities than calcineurin inhibitors but comes at a cost of increased incidence and severity
of acute rejection, potentially due to its deleterious effect on both the number and function of
Foxp3+ regulatory T cells (Tregs). TIGIT is a CD28 family coinhibitory receptor expressed on
several subsets of immune cells including Tregs. We hypothesized that coinhibition through
TIGIT signaling could function to ameliorate costimulation blockade-resistant rejection. The …