[HTML][HTML] CTLA4-Ig restores rejection of MHC class-II mismatched allografts by disabling IL-2-expanded regulatory T cells
LM Charbonnier, B Vokaer, PH Lemaitre… - American Journal of …, 2012 - Elsevier
Allograft acceptance and tolerance can be achieved by different approaches including
inhibition of effector T cell responses through CD28-dependent costimulatory blockade and
induction of peripheral regulatory T cells (Tregs). The observation that Tregs rely upon CD28-
dependent signals for development and peripheral expansion, raises the intriguing
possibility of a counterproductive consequence of CTLA4-Ig administration on tolerance
induction. We have investigated the possible negative effect of CTLA4-Ig on Treg-mediated …
inhibition of effector T cell responses through CD28-dependent costimulatory blockade and
induction of peripheral regulatory T cells (Tregs). The observation that Tregs rely upon CD28-
dependent signals for development and peripheral expansion, raises the intriguing
possibility of a counterproductive consequence of CTLA4-Ig administration on tolerance
induction. We have investigated the possible negative effect of CTLA4-Ig on Treg-mediated …