Impact of warm ischemia on different leukocytes in bronchoalveolar lavage from mouse lung: possible new targets to condition the pulmonary graft from the non–heart …

N Geudens, BM Vanaudenaerde, AP Neyrinck… - The Journal of heart and …, 2006 - Elsevier
BACKGROUND: The use of non–heart-beating donors (NHBDs) for lung transplantation is a
possible alternative for increasing the number of organs available. The warm ischemic
period after circulatory arrest may contribute to a higher degree of primary graft dysfunction,
resulting from ischemia–reperfusion injury (IRI). A better understanding of the role of
inflammatory cells during the warm ischemic interval may be useful for developing new
therapeutic strategies against IRI. METHODS: Mice were divided in 7 groups (n= 6/group). In …