KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA
H Zeng, D Zhao, D Mukhopadhyay - Journal of Biological Chemistry, 2002 - ASBMB
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) functions by
activating two receptor tyrosine kinases, Flt-1 (VEGFR-1) and KDR (VEGFR-2), both of which
are selectively expressed on the primary vascular endothelium. KDR is responsible for
VPF/VEGF-stimulated endothelial cell (EC) proliferation and migration, whereas Flt-1 down-
modulates KDR-mediated EC proliferation. Flt-1 mediates down-regulation of EC
proliferation through pertussis toxin-sensitive G proteins, βγ subunits, small GTPase CDC42 …
activating two receptor tyrosine kinases, Flt-1 (VEGFR-1) and KDR (VEGFR-2), both of which
are selectively expressed on the primary vascular endothelium. KDR is responsible for
VPF/VEGF-stimulated endothelial cell (EC) proliferation and migration, whereas Flt-1 down-
modulates KDR-mediated EC proliferation. Flt-1 mediates down-regulation of EC
proliferation through pertussis toxin-sensitive G proteins, βγ subunits, small GTPase CDC42 …
