Rapid transactivation of the vascular endothelial growth factor receptor KDR/Flk-1 by the bradykinin B2 receptor contributes to endothelial nitric-oxide synthase …
D Thuringer, L Maulon, C Frelin - Journal of Biological Chemistry, 2002 - ASBMB
Bradykinin (BK) and vascular endothelial growth factor (VEGF)-165 stimulate vasodilatation,
microvascular permeability, and angiogenesis via the activation of the B2-type and KDR/Flk-
1 receptors. To delineate the signal transduction pathways distal to the receptor activation in
microvascular permeability, we compared their effects on two downstream targets, ie
endothelial nitric-oxide (NO) synthase (eNOS) and F-actin, in primary cultures of cardiac
capillary endothelial cells. The two mediators induced a similar cytoskeletal reorganization …
microvascular permeability, and angiogenesis via the activation of the B2-type and KDR/Flk-
1 receptors. To delineate the signal transduction pathways distal to the receptor activation in
microvascular permeability, we compared their effects on two downstream targets, ie
endothelial nitric-oxide (NO) synthase (eNOS) and F-actin, in primary cultures of cardiac
capillary endothelial cells. The two mediators induced a similar cytoskeletal reorganization …
